Week 4 is here, and the NFL has another loaded slate on tap. Is this a make-or-break week for teams so soon in the season? You bet it is! The Dolphins, Bucs, Chargers, and Texans are all in jeopardy of falling to 0-4 on the season. And even though there are 13 games left after Week 4, falling to 0-4 puts a team’s postseason odds in flux.

This week, we have early-morning football! The Colts and Commanders square off at 9:30 am ET from London, England. That will be followed up by several intriguing 1:00 PM matchups, four late-afternoon games, Sunday Night Football featuring the Lions, and a Monday night NFC South battle.

Here’s the complete Week 4 schedule and current DraftKings odds. Lines are subject to change.

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Sunday Morning — London

9:30 AM ET

• Indianapolis Colts (-4.5) at Washington Commanders — OVER/UNDER 47.5 — 9:30 AM

The NFL’s first international game of the 2026 season takes place at Tottenham Hotspur Stadium in London. CBS Sports

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Sunday Afternoon — 1:00 PM ET

• New England Patriots at Buffalo Bills (-7) — OVER/UNDER 48.5 — 1:00 PM
• Tennessee Titans at Baltimore Ravens (-11.5) — OVER/UNDER 43.5 — 1:00 PM
• Jacksonville Jaguars at Cincinnati Bengals (-2.5) — OVER/UNDER 51.5 — 1:00 PM
• Dallas Cowboys at Houston Texans (-2.5) — OVER/UNDER 48.5 — 1:00 PM
• New York Jets at Chicago Bears (-3.5) — OVER/UNDER 43.5 — 1:00 PM
• Green Bay Packers (-3.5) at Tampa Bay Buccaneers — OVER/UNDER 39.5 — 1:00 PM
• Los Angeles Rams (-3.5) at Philadelphia Eagles — OVER/UNDER 43.5 — 1:00 PM
• Arizona Cardinals (-2.5) at New York Giants — OVER/UNDER 44.5 — 1:00 PM

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Sunday Afternoon — 4:05 PM ET

• Miami Dolphins at Minnesota Vikings (-10.5) — OVER/UNDER 38.5 — 4:05 PM

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Sunday Afternoon — 4:25 PM ET

• Kansas City Chiefs (-4.5) at Las Vegas Raiders — OVER/UNDER 47.5 — 4:25 PM
• Los Angeles Chargers at Seattle Seahawks (-7) — OVER/UNDER 42.5 — 4:25 PM
• Denver Broncos at San Francisco 49ers (-3) — OVER/UNDER 47.5 — 4:25 PM

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Sunday Night Football — 8:20 PM ET

• Detroit Lions (-3.5) at Carolina Panthers — OVER/UNDER 50.5 — 8:20 PM

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Monday Night Football — 8:15 PM ET

• Atlanta Falcons at New Orleans Saints (-3) — OVER/UNDER 48.5 — 8:15 PM

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SOD Week 4 Games To Watch — Best Bets

🔥 Patriots at Bills
🔥 Jaguars at Bengals
🔥 Cowboys at Texans
🔥 Chiefs at Raiders
🔥 Broncos at 49ers
🔥 Lions at Panthers

There are several key games to keep an eye on this weekend, including a matchup of the undefeated Chiefs facing the undefeated Raiders! Yes, the Raiders are 3-0 and could be all alone in first place in the AFC West if they defeat the Chiefs today.

Our best bets now sit at 6-1 on the season. Let’s keep it rolling!

Best Bets Week 4

• Commanders +4.5
• Bengals -2.5
• Giants +2.5
• Jets +3.5
• Broncos +3
• Lions -3.5