Week 1 NFL 2022: Odds, TV Schedule, Best Bets

The NFL 2020 season kicks off tonight when the Super Bowl champion Los Angeles Rams host the Buffalo Bills on Thursday Night Football. While the Rams dominated the NFC last year on their way to winning the Super Bowl under new QB Matt Stafford, they find themselves as a Vegas underdog in their home opener vs. Buffalo.

The Bills are a great team, however, it does seem a bit odd to see the defending champs as the home dog in Week 1. Nevertheless, we are hoping to start off hot with our NFL picks!

Last week, our NCAA picks finished a stout 4-1 and should have been a perfect 5-0 if OSU didn’t pull a 4th quarter disappearing act vs. Central Michigan.

While we love to break down games with stats, commentary, and other figures every week here at SOD, this week we aren’t wasting any time with chit-chat! Just like Week 1 for our college picks, we are diving right in!

NFL Week 1 Schedule, best bets, TV start times

Without further ado, here is your Week 1 schedule, current Vegas odds, TV start times and best bets.

Thursday, Sept. 8

  • Buffalo Bills (-2) at Los Angeles Rams – 8:20 p.m. ET

Sunday, Sept. 11

  • Indianapolis Colts (-7) at Houston Texans – 1 p.m. ET — CBS
  • Pittsburgh Steelers at Cincinnati Bengals (-6.5) – 1 p.m. ET — CBS
  • Baltimore Ravens (-7) at New York Jets – 1 p.m. ET — CBS
  • Philadelphia Eagles (-3.5) at Detroit Lions – 1 p.m ET — FOX
  • New Orleans Saints (-5.5) at Atlanta Falcons – 1 p.m. ET — FOX
  • San Francisco 49ers (-6.5) at Chicago Bears – 1 p.m. ET — FOX
  • Jacksonville Jaguars (+2.5) at Washington Commanders – 1 p.m. ET
  • New England Patriots at Miami Dolphins (-3) – 1 p.m. ET — CBS
  • Cleveland Browns at Carolina Panthers (-1) – 1 p.m. ET — CBS
  • New York Giants at Tennessee Titans (-5.5) – 4:25 p.m. ET — FOX
  • Green Bay Packers (-1.5) at Minnesota Vikings – 4:25 p.m. ET — FOX
  • Las Vegas Raiders at Los Angeles Chargers (-3) – 4:25 p.m. ET — CBS
  • Kansas City Chiefs (-4.5) at Arizona Cardinals – 4:25 p.m. ET — CBS
  • Tampa Bay Buccaneers (-2.5) at Dallas Cowboys — 8:20 p.m. ET — NBC

Monday, Sept. 12

  • Denver Broncos (-6.5) at Seattle Seahawks – 8:15 p.m. ET — ESPN

Picks — Buffalo -2.5, Indy -7, Lions +3.5, Miami -3, Panthers -1

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